Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age – New Study
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02241-4
Wells et al. profile RNA and surface protein expression to describe dominant tissue-specific effects on immune cell composition and function across lineages in the human tissues across age.
Summary
Wells et al. in Nature Immunology (August 2025) present a comprehensive analysis of human immune cell populations across various tissues and ages. Using RNA and surface protein profiling, they identify dominant tissue-specific factors influencing immune cell composition and function. This study highlights how location within the body significantly shapes the characteristics of immune cells, regardless of lineage. Their findings provide valuable insights into the complexities of the human immune system and its adaptation to diverse tissue environments throughout the lifespan.
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