Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt – New Study
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02240-5
Colonna and colleagues show that the clock genes encoding REV-ERBα and REV-ERBβ maintain ILC3 functions in the gut by controlling the expression of RORγt.
Summary
Colonna et al. discovered that the circadian rhythm-related genes, specifically those encoding REV-ERBα and REV-ERBβ, play a crucial role in maintaining the proper function of intestinal innate lymphoid cells 3 (ILC3s). Their research, published in Nature Immunology, demonstrates that these “clock genes” regulate the expression of RORγt, a transcription factor essential for ILC3 development and function. This suggests that the body’s internal clock directly influences gut immunity by controlling the activity of these vital immune cells. Understanding this link could lead to new therapeutic strategies targeting circadian rhythms to modulate gut inflammation and immunity.
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