Nature Immunology, Published online: 18 August 2025; doi:10.1038/s41590-025-02230-7

Latz et al. review the molecular mechanisms that drive NLRP3 inflammasome activation and regulation, and discuss emerging targeting strategies.



Summary

In a review published in Nature Immunology, Latz et al. delve into the intricate workings of the NLRP3 inflammasome. They explore the molecular mechanisms responsible for its activation, a crucial process in immune responses and inflammation. The review also focuses on the regulatory mechanisms that govern the NLRP3 inflammasome, preventing overactivation and potential harm. Furthermore, the authors highlight and discuss promising, novel therapeutic strategies aimed at targeting this vital inflammasome pathway, potentially opening avenues for treating various inflammatory diseases.

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