Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02222-7

As interest in tissue-resident immunity, mucosal vaccines and host–microbiota interactions increases, barrier immunology stands at the forefront of immune defense.



Summary

Barrier immunology is increasingly relevant as research focuses on tissue-resident immunity, mucosal vaccines, and the interplay between hosts and their microbiota. This field is positioned as a critical area in understanding immune defense mechanisms, particularly at mucosal surfaces and other interfaces with the external environment. The rising interest in these interconnected areas underscores the importance of barrier immunology in developing effective strategies for preventing and treating diseases at these key locations.

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