CAR T cell therapy for children with rheumatic disease: the time is now



Summary

CAR T-cell therapy, traditionally used for cancer, is showing promise in treating severe, refractory rheumatic diseases in children. These diseases often involve an overactive immune system, and CAR T-cells can effectively reset it. Early results are encouraging, demonstrating significant improvements in disease activity and quality of life. While long-term effects and potential toxicities need further study, the benefits observed so far suggest that CAR T-cell therapy is a viable and potentially transformative treatment option for children with rheumatic diseases that are resistant to conventional therapies. Further research and clinical trials are crucial to optimize its use and ensure its safety in this vulnerable population.

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