The liver metabolizes dietary galactose to fuel antitumour T cell immunity



Summary

Dietary galactose, often overlooked, plays a crucial role in fueling anti-tumor T cell responses, particularly when metabolized in the liver. The liver’s efficient galactose metabolism pathway provides T cells with essential energy and promotes their cytotoxic activity against cancer cells. This process enhances T cell infiltration into tumors and improves overall anti-tumor immunity. This finding highlights the importance of considering dietary factors and metabolic pathways, like hepatic galactose metabolism, in designing effective cancer immunotherapies. Manipulating galactose metabolism could potentially augment the efficacy of existing treatments by bolstering T cell function within the tumor microenvironment.

Read more…

Credits: Source

This post is part of “Science/Immunology News”, Follow for more…!!!