Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer



Summary

A new study reveals that caffeine boosts the immune system’s ability to fight colorectal cancer by targeting the kynurenine pathway. Caffeine inhibits this pathway, reducing the production of immunosuppressive metabolites like kynurenine. This, in turn, enhances the activity of antitumor T-cells, critical components of the immune system responsible for directly attacking cancer cells. The findings suggest that caffeine, a readily available compound, could be a promising therapeutic adjunct to enhance immunotherapy efficacy in treating colorectal cancer.

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