Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification



Summary

This research presents a novel method for isolating and enriching tumor-reactive T-cells, crucial for effective cancer immunotherapy. It involves creating “artificial antigen presenting cells” (aAPCs) using superparamagnetic nanoparticles coated with polymers and relevant antigens. These aAPCs capture T-cells with specific receptors. By applying a magnetic field, researchers can easily isolate these antigen-specific T-cells. This enriched T-cell population is then used to identify neoantigens (new antigens specific to tumor cells), which can be targeted for personalized cancer treatments. This approach offers a potentially powerful tool for improving T-cell based immunotherapies and identifying effective cancer targets.

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