CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation



Summary

Augmenting CAR-T cells with CD2 enhances their anti-tumor efficacy by improving the immunological synapse. This involves restructuring the synapse architecture for stronger and more sustained T-cell receptor (TCR) signaling. Specifically, CD2 engagement strengthens the interaction between CAR-T cells and tumor cells, promoting more efficient target cell lysis. Furthermore, CD2 co-stimulation helps to counteract T-cell exhaustion, a major limitation in CAR-T cell therapy. By reducing exhaustion markers and maintaining a more functional phenotype, CD2-enhanced CAR-T cells demonstrate superior persistence and long-term anti-tumor activity. This strategy offers a promising approach for improving the overall effectiveness of CAR-T cell immunotherapy.

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