Is immune effector cell-associated enterocolitis a CAR T-cell lymphoproliferative disorder?



Summary

Immune effector cell-associated enterocolitis (IEC-associated enterocolitis) can manifest after CAR T-cell therapy, presenting with gastrointestinal inflammation. While resembling graft-versus-host disease (GVHD), it’s often distinct, raising questions about its underlying mechanisms. Emerging evidence suggests a potential link to T-cell lymphoproliferative disorders. Characterized by T-cell clonality and expansion, these disorders can cause inflammatory pathologies. Research aims to clarify if IEC-associated enterocolitis stems from a similar T-cell dysregulation triggered by CAR T-cell therapy, potentially impacting treatment strategies and patient outcomes. Further investigation is needed to confirm this link and understand the specific T-cell populations involved.

Read more…

This post is part of “Science/Immunology News”, Follow for more…!!!