Endogenous T cell responses to fusion-derived neoantigens in pediatric acute leukemias



Summary

Pediatric acute leukemias, particularly those with fusion oncogenes, can generate unique neoantigens derived from the fusion point. Research has shown that the immune system, specifically T cells, can recognize and respond to these fusion-derived neoantigens. This recognition triggers endogenous T cell responses, potentially offering a natural mechanism for controlling leukemia. These T cell responses can be detected using MHC-multimer staining and functional assays. Understanding the specificity and breadth of these T cell responses holds promise for developing immunotherapies targeting fusion-specific neoantigens, offering a more targeted and potentially less toxic approach to treating these leukemias.

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