Multiple Positions – 07 PhD Degree-Fully Funded at Leiden University, Netherlands

Education, Research & Positions
Dr AF Saeed
6th August 2025
0
21 minutes read

Leiden University, Netherlands invites online Application for number of Fully Funded PhD Degree at various Departments. We are providing a list of Fully Funded PhD Programs available at Leiden University, Netherlands.

Eligible candidate may Apply as soon as possible.

(01) PhD Degree – Fully Funded

PhD position summary/title: PhD Candidate in Immuno-biology and Infectious disease

The Faculty of Science Leiden, the Leiden Institute of Biology and Leiden Institute of Chemistry are looking for a PhD candidate to pursue research on the development of host-directed therapeutics for mycobacterial infections.

Mycobacterial infections are among the top 10 cause of death globally. Although cases of tuberculosis (Mtb) are typically decreasing because of concerted global efforts, respiratory infections cause by non-tuberculous mycobacteria (NTM), such as M. avium, have more than doubled since the year 2000. The increase in antibiotic resistance is a major concern for both Mtb and NTM, and there is need for novel therapeutics. This PhD project investigates the potential of targeting host-cell metabolism to deprive intracellular bacteria of essential nutrients and boost the immune response. The candidate will work as part of an interdisciplinary team to help characterize how pathogenic mycobacteria rewire host-cell metabolism and identify novel drug targets. They will be trained in a variety of powerful, modern analytic techniques including metabolomics, transcriptomics, and proteomics and work on advanced biological systems for modelling infection including macrophages, organoids, zebrafish, primary and clinical samples.
Embedding within the Institutes of Biology and Chemistry at Leiden will enable the candidate to maximize their learning opportunities, participate in local research networks, and access leading research facilities.

Deadline : 1 November 2025

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(02) PhD Degree – Fully Funded

PhD position summary/title: PhD candidate in Design and synthesis of pyrophosphate mimetics to study enzymes involved in natural

The Faculty of Science Leiden and Leiden Institute of Chemistry are looking for a PhD candidate in the design and synthesis of pyrophosphate mimetics to study enzymes involved in natural ADP-ribosylation.

ADP-ribosylation (ADPr) is a common but poorly understood post-translational modification of proteins, with a confirmed role in various physiological processes such as DNA repair and antiviral defense. Protein targets are enzymatically modified with ADP-ribose by ADP-ribosyltransferases of the PARP family, while ADP-ribosylhydrolases remove the ADP-ribose residue. Understanding the detailed mechanisms of such modification and demodification is vital to uncover the regulatory functions of ADP-ribosylation and to develop innovative therapies for cancer, viral infections, neurodegenerative, and autoimmune diseases.

The goal of the proposed research is to design and synthesize a range of well-defined substrate mimics, inhibitors, and probes to target various ADP-ribosyltransferases and ADP-ribosyl hydrolases, to enable a better understanding of their catalytic mechanism, specificity, and regulatory role. The project will be carried out as a collaborative effort with researchers from the fields of chemical and structural biology of ADP-ribosylation.

Deadline : 20 September 2025

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View All Fully Funded PhD Positions Click Here

(03) PhD Degree – Fully Funded

PhD position summary/title: PhD Candidate, Efficient LLM Algorithm, Hardware and System Design (1.0 FTE)

We are seeking a highly motivated PhD candidate to develop efficient on-device generative AI systems based on large language models (LLMs). The project focuses on creating compact, low-latency, and energy-efficient LLM following a hardware-software co-design approach that enables real-time computation on resource-constrained devices. Example applications include portable speech understanding and rehabilitation tools for speech disorders, real-time language processing for human-robot interaction, and adaptive content generation in augmented and virtual reality environments. The project combines algorithm design, model compression, and custom hardware acceleration to advance the state of the art in edge LLM. This position offers a unique opportunity to be at the forefront of technological advancements that promise to reshape the future. You will have the chance to participate in actual silicon tape-outs and gain hands-on experience across the complete design flow, including specialized training in both front-end and back-end integrated circuit design. Additionally, you will have access to substantial computing resources to develop and experiment with LLMs.

Deadline : 30 September 2025

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(04) PhD Degree – Fully Funded

PhD position summary/title: PD position: Development of high-temperature STM

Applications are invited for a postdoctoral position in the group of Prof. Dr. Irene M.N. Groot. The candidate will develop an operando scanning tunneling microscope suitable for studies of catalytic reactions up to temperatures of 1200 K (high-temperature ReactorSTM). The work will focus on the development and testing of new piezoelectric materials that can withstand the high temperatures of this new scanning tunneling microscope. This will require sourcing materials capable of withstanding the desired temperatures and pressures while providing the necessary piezoelectric and mechanical properties needed for fabrication into STM scanner tubes. Once suitable tubes have been fabricated and the necessary modifications (e.g. creating electrodes, integrating into scanner components) have been made to turn them into STM scanning actuators, experimental work will begin to assess the performance of the scanners.

Deadline : 19 August 2025

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(05) PhD Degree – Fully Funded

PhD position summary/title: PhD candidate in photoactivated chemotherapy

Photoactivated chemotherapy (PACT) is a new form of phototherapy against cancer. In the frame of an Institute-funded programme dedicated to developing new photocages for cancer treatment, the group of Prof. Sylvestre Bonnet is looking for a chemist with proven experience in synthetic bioinorganic chemistry, photochemistry or photopharmacology, and/or chemical biology, to investigate the photocaging of amines. Do you have interest in photomedicine? Do you want your research to make an impact? Just apply and join the Bonnet group! Experience with photodynamic therapy, pancreatic cancer, and/or DFT modelling, are a plus.

The position entails the synthesis of new ruthenium-based photocages. You will be integrated in the MCBIM group (https://www.universiteitleiden.nl/en/science/chemistry/mcbim) and share responsibility of the chemical-biological part of the group, with involvement in the supervision of undergraduate students (BSc and MSc) and teaching tasks at the institute level (supervision of practicum and exercise sessions). You will work in collaboration with the other members of the group and actively participate to group meetings.

Deadline : 31 August 2025

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Polite Follow-Up Email to Professor : When and How You should Write

Click here to know “How to write a Postdoc Job Application or Email”

(06) PhD Degree – Fully Funded

PhD position summary/title: PhD candidate in the field of structural biology

Mycobacterium tuberculosis is a leading cause of mortality worldwide. A critical factor in its survival and pathogenicity is the ability to acquire nutrients across the highly impermeable, mycolic acid-rich outer membrane of the mycobacterial cell envelope. This membrane functions as a selective barrier, conferring intrinsic resistance to many antibiotics while also complicating nutrient uptake. However, the molecular mechanisms underlying nutrient transport across this barrier remain poorly understood.

Our lab focuses on a specialized transport system in mycobacteria involving members of the PPE protein family, which have been implicated in the uptake of small molecules such as sugars, siderophores, and ions across the outer membrane.

In this PhD project, the student will investigate the three-dimensional structure and molecular mechanism of PPE porins using biochemical, microbiological, and biophysical approaches, with an emphasis on cryo-electron microscopy. We aim to determine how PPE proteins mediate selective small-molecule transport and how structural insights into these outer membrane porins can guide drug development strategies to enhance compound uptake.

Deadline : 15 August 2025

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(07) PhD Degree – Fully Funded

PhD position summary/title: PhD position within the project “What’s wrong? Ancient corrections in Greek papyri from Egypt” (AnCo

The Greek papyrus corpus provides an important source for our knowledge of the ancient world and offers an excellent opportunity to study the Greek language as written by non-scholarly writers in antiquity. This project will collect, annotate and study the ancient corrections in this corpus to learn more about the Postclassical Greek language, the process of composition of papyrus documents and the backgrounds of their writers.

A multidisciplinary team of three researchers and a research assistant will analyse ancient corrections at different levels of language production (from spelling and morphology to semantics and phraseology) across a range of different (documentary) genres with the following three key objectives: (1) to create an annotated open-access relational database of ancient corrections in Greek papyri, (2) to study Postclassical Greek spelling from below, as produced and corrected by the ancient writers themselves, and (3) to identify the stage of composition of a textual object and make this category an integrated part of the analysis of papyrus documents.

Deadline : 15 August 2025

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About Leiden University, Netherlands –Official Website

Leiden University (abbreviated as LEI; Dutch: Universiteit Leiden) is a public research university in Leiden, Netherlands. It was founded as a Protestant university in 1575 by William, Prince of Orange as the first university in the Netherlands.

During the Dutch Golden Age scholars from around Europe were attracted to the Dutch Republic for its climate of intellectual tolerance. Individuals such as René Descartes, Rembrandt, Christiaan Huygens, Hugo Grotius, Benedictus Spinoza, and later Baron d’Holbach were active in Leiden and environs.

The university has seven academic faculties and over fifty subject departments, housing more than forty national and international research institutes. Its historical primary campus consists of several buildings spread over Leiden, while a second campus located in The Hague houses a liberal arts college (Leiden University College The Hague) and several of its faculties. It is a member of the Coimbra Group, the Europaeum, and a founding member of the League of European Research Universities.

The university has produced twenty-six Spinoza Prize Laureates and sixteen Nobel Laureates. Members of the Dutch royal family such as Queen Juliana, Queen Beatrix, and King Willem-Alexander are alumni, and ten prime ministers of the Netherlands including Mark Rutte. US President John Quincy Adams also studied at the university.

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