The findings challenge long-standing assumptions about therapy-related cancers. They also highlight how drug actions can substitute for genetic changes in tumor development. An international team of researchers, including Prof. Kirsten Kübler from the Berlin Institute of Health at Charité (BIH) and collaborators at the Broad Institute of MIT and Harvard, Mass General Brigham, and the […]



Summary

A recent study challenges conventional understanding of therapy-related cancers, revealing drug actions can mimic genetic mutations in driving tumor development. This international research team, including Prof. Kübler from BIH and collaborators from MIT, Harvard, and Mass General Brigham, suggests that drug-induced changes can be just as potent as genetic alterations in cancer formation. This discovery underscores the need to reassess how therapies influence tumor development and consider non-genetic mechanisms alongside genetic factors when understanding and treating therapy-related cancers.

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