For 40 years, researchers relied on horseshoe crab blood to catch endotoxins in drugs. Now, synthetic alternatives and updated regulations can end the practice.



Summary

For decades, horseshoe crab blood has been vital for ensuring drug safety by detecting bacterial endotoxins. This practice, driven by a lack of alternatives, has impacted horseshoe crab populations. However, the tide is turning. Synthetic reagents offer a viable, cruelty-free alternative to crab blood. Coupled with updated regulations acknowledging these alternatives, the pharmaceutical industry can now transition away from relying on the unique properties of horseshoe crab blood. This shift promises to protect these ancient creatures while maintaining stringent drug safety standards.

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