A toxic mold once feared for causing mysterious deaths in ancient tombs is now at the center of a medical breakthrough. Scientists at Penn have engineered compounds from Aspergillus flavus—a fungus blamed for the “pharaoh’s curse”—into powerful cancer-fighting molecules called asperigimycins. These unique, ring-shaped peptides not only rival FDA-approved leukemia drugs but also offer clues […]



Summary

Scientists are repurposing the toxic mold Aspergillus flavus, infamous for the “pharaoh’s curse,” into potent cancer-fighting agents. Researchers at Penn have engineered the mold’s compounds into asperigimycins, ring-shaped peptides that show promise in treating leukemia. These molecules exhibit comparable effectiveness to existing FDA-approved drugs. This breakthrough not only offers a potential new treatment avenue for cancer but also provides insight into developing further novel therapies.

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