Fungi are increasingly resistant to antifungals, and the variation in resistance has significantly increased. This is evident from the analysis of more than 12,000 lung samples collected over 30 years in Dutch hospitals. In addition, a resistant infection in a patient almost always consists of different fungal strains, making treatment more challenging.



Summary

A 30-year Dutch study of over 12,000 lung samples reveals a concerning rise in antifungal resistance among fungi, with a significant increase in the variety of resistance patterns observed. This means fungi are evolving to evade treatment in multiple ways. Furthermore, resistant infections within a single patient are typically comprised of multiple fungal strains. This complexity makes these infections harder to eradicate, as treatment must address a wider range of resistance mechanisms. The study highlights the urgent need for new antifungal strategies to combat these evolving threats.

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