Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell’s demolition and recycling pathways, pharmaceutical researchers have been able to develop novel therapies for otherwise drug-resistant diseases.



Summary

Molecular glues are revolutionizing drug discovery by offering a unique approach to target previously “undruggable” diseases. These small molecules work by physically linking two proteins together: a disease-causing protein and a protein that flags it for cellular degradation. This induced proximity leads to the destruction of the harmful protein, offering a powerful therapeutic strategy. Researchers are actively exploring molecular glues as potential treatments for various diseases, particularly those resistant to traditional therapies, by harnessing the body’s own cellular recycling mechanisms.

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