Frank Buchholz shares how his laboratory improves upon the latest gene editing techniques by designing programmable recombinases.



Summary

Frank Buchholz’s lab focuses on advancing gene editing beyond traditional CRISPR-Cas systems. They engineer programmable recombinases, enzymes that can precisely cut and paste DNA sequences, offering enhanced control and specificity compared to CRISPR. This approach involves designing recombinases that recognize custom target sites, allowing for more tailored genome modifications. By refining these techniques, Buchholz’s research aims to create more precise and efficient gene editing tools with potential applications in treating genetic diseases and engineering novel biological systems.

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