UGCG and the glycosphingolipid rheostat: a metabolic checkpoint governing immune activation and tumor immune evasion Summary UDP-glucose ceramide glucosyltransferase (UGCG) controls the “glycosphingolipid rheostat,” a metabolic checkpoint pivotal in immune responses and tumor immune evasion. Read More
Cascade amplification of therapeutic payloads for cancer immunotherapy Summary “Cascade amplification of therapeutic payloads” in cancer immunotherapy refers to strategies designed to enhance the efficacy of delivered drugs or immunomodulatory agents within the tumor microenvironment. Read More
Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2 Summary Regulatory T cell (Treg) therapy, intended to suppress inflammation, can paradoxically trigger inflammatory responses in certain contexts. Research Read More
Nature Reviews Immunology, Published online: 07 August 2025; doi:10.1038/s41577-025-01207-9 Fifty years ago, Köhler and Milstein introduced the world to hybridoma technology for the generation of monoclonal antibodies. Scientists have subsequently built upon Read More
Caerin 1.1/1.9 interfere KHDRBS1-DDX5 regulatory axis to induce IL-18 mediated pyroptosis in a HeLa cell tumour model Summary Caerin 1.1 and 1.9, peptides, disrupt the KHDRBS1-DDX5 regulatory axis in HeLa cancer cells. This disruption triggers IL-18 Read More
Nature Immunology, Published online: 23 July 2025; doi:10.1038/s41590-025-02223-6 The tumor environment is nutrient deficient. Here the authors show that early availability of methionine is critical for optimal T cell activation and prevents T Read More
Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules Summary Mice were engineered to express a diverse range of human T cell receptors (TCRs) selected based on their Read More
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