Researchers in Germany have uncovered a hidden receptor, GPR133, that plays a vital role in bone strength. By activating it with a new compound called AP503, they boosted bone density in mice and even reversed Read More
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Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02249-w Carboxylation switch Summary A groundbreaking study published in Nature Immunology reveals a novel “carboxylation switch” mechanism in immune regulation. Researchers discovered that specific immune cells Read More
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Autoinhibition imposed by a large conformational switch of INO80 regulates
Science, Volume 389, Issue 6757, July 2025. Summary To provide a summary, I need the actual content of Science, Volume 389, Issue 6757, from July 2025. Since that issue hasn’t been published yet, I can’t summarize it. I need Read More
Worms offer a simple yet powerful whole-organism model for studying senescence, mirroring mammalian aging processes and enabling research into age-related diseases and dormant cancer therapies. Researchers triggered a senescent-like state in worms by altering the Read More
Abstract Abs play a pivotal role in adaptive immunity by binding to pathogens and initiating immune responses against infections. Processes such as somatic hypermutation and class switch recombination (CSR) enhance Ab affinity and effector functions. Read More
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