Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02247-y Using in vivo CRISPR–Cas9 screens of CD8+ T cells in a melanoma model, we identified STUB1 as an inhibitor of T cell-mediated antitumor immunity. Read More
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The membrane skeleton is constitutively remodeled in neurons by calcium
Science, Volume 389, Issue 6760, August 2025. Summary Without specific article titles or content details from the mentioned Science issue, I can only offer a generic summary. Science, Volume 389, Issue 6760, published in August 2025, likely features cutting-edge research across Read More
Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02217-4 Sajti and colleagues identify TREM2 as a critical factor in myeloid cells in response to hyperoxia-induced lung injury in neonates, finding that TREM2 deficiency protects Read More
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Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment
Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation Summary Metabotropic glutamate receptor 4 (mGluR4) signaling in dendritic cells (DCs) significantly alters the tumor microenvironment. Activation of mGluR4, a glutamate Read More
Abstract Abs play a pivotal role in adaptive immunity by binding to pathogens and initiating immune responses against infections. Processes such as somatic hypermutation and class switch recombination (CSR) enhance Ab affinity and effector functions. Read More
Education, Research & Positions
TP53 Codon 72 Polymorphism Impacts Macrophage Activation through Reactive Oxygen
Abstract The role of the most common TP53 single-nucleotide polymorphism (SNP) at codon 72, which encodes for proline (P72) or arginine (R72), in the regulation of the immune system has not yet been thoroughly explored. We Read More
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