Nature Reviews Immunology, Published online: 01 September 2025; doi:10.1038/s41577-025-01225-7 Populations of regulatory KIR+CD8+ T cells expand during pregnancy and can promote maternal tolerance to the developing fetus. Summary A Nature Reviews Immunology Read More
Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2 Summary Regulatory T cell (Treg) therapy, intended to suppress inflammation, can paradoxically trigger inflammatory responses in certain contexts. Research Read More
Natural genetic variation in the genome ensures biodiversity and drives evolution. However, as natural evolutionary processes require millennia, we cannot wait for them to adapt crop plants to the rapidly changing climatic conditions. To safeguard Read More
Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target Summary This study used a comprehensive “multi-omics” approach (combining genomics, proteomics, etc.) to understand the T-cell environment Read More
Caerin 1.1/1.9 interfere KHDRBS1-DDX5 regulatory axis to induce IL-18 mediated pyroptosis in a HeLa cell tumour model Summary Caerin 1.1 and 1.9, peptides, disrupt the KHDRBS1-DDX5 regulatory axis in HeLa cancer cells. This disruption triggers IL-18 Read More
Nature Immunology, Published online: 16 July 2025; doi:10.1038/s41590-025-02210-x Feuerer and colleagues use multiomic analyses to identify DNA methylation, chromatin accessibility and gene expression programs that govern the tissue adaptation of human skin Treg Read More
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