Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02257-w Cui and colleagues identify the chromatin organizer protein SATB1 as a critical regulator of quiescence in stem-like progenitor CD8+ T cells that arise during chronic Read More
Tags :regulator
Agonistic immune checkpoint regulator may harm the heart Summary Agonistic immune checkpoint regulators (AICRs), designed to enhance anti-tumor immunity, may pose a risk to the heart. While AICRs like CD40 agonists are showing promise in Read More
Education, Research & Positions
Identification of the Notch ligand DLK1 as an immunotherapeutic target
Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma Summary Adrenocortical carcinoma (ACC) is an aggressive cancer with limited treatment options. This research Read More
Education, Research & Positions
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion Summary Research indicates that the prostacyclin receptor, PTGIR, plays a crucial role in regulating CD8+ T cell exhaustion, a state of Read More
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