plasticity Archives

Clock genes tune plasticity of group 3 innate lymphoid cells

Dr AF Saeed Dr AF Saeed 13th August 2025

Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02245-0 Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central Read More

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Circadian circuits control plasticity of group 3 innate lymphoid cells

Dr AF Saeed Dr AF Saeed 13th August 2025

Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02240-5 Colonna and colleagues show that the clock genes encoding REV-ERBα and REV-ERBβ maintain ILC3 functions in the gut by controlling the expression of RORγt. Read More

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Identification of the Notch ligand DLK1 as an immunotherapeutic target

Dr AF Saeed Dr AF Saeed 3rd July 2025

Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma Summary Adrenocortical carcinoma (ACC) is an aggressive cancer with limited treatment options. This research Read More

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Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory

Dr AF Saeed Dr AF Saeed 27th June 2025

Nature Immunology, Published online: 27 June 2025; doi:10.1038/s41590-025-02206-7 Ciofani and colleagues examine the plasticity of Tγδ17 cells in the gut, where they identify a role for the AP-1 transcription factors JUNB and FOSL2 Read More