Mutation Archives

T cells engineered to target a shared β-catenin mutation eradicate

Dr AF Saeed Dr AF Saeed 10th September 2025

T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice Summary Genetically engineered T cells targeting a specific mutation in the β-catenin protein have shown remarkable success in eradicating solid tumors Read More

Education, Research & Positions

TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid

Dr AF Saeed Dr AF Saeed 27th August 2025

Nature Immunology, Published online: 27 August 2025; doi:10.1038/s41590-025-02252-1 TCR-T cells are T cells engineered to express a specific T cell receptor. Here the authors present a TCR-T cell that targets CTNNB1-S37F, Read More

Education, Research & Positions

The Rare Mutation That Makes People Immune to Viruses –

Dr AF Saeed Dr AF Saeed 23rd August 2025

Some people carry a rare mutation that makes them resistant to viruses. Now scientists have copied that effect with an experimental mRNA therapy that stopped both flu and COVID in animal trials — raising hopes for Read More

Education, Research & Positions

Could a Common Blood Mutation Be the Key to Preventing

Dr AF Saeed Dr AF Saeed 7th July 2025

Unexpected mutations in blood stem cells may help protect against Alzheimer’s disease. A new study published in the journal Cell Stem Cell suggests that certain genetic changes in blood stem cells may offer protection Read More