Nature Immunology, Published online: 22 September 2025; doi:10.1038/s41590-025-02285-6 The authors spatially and functionally map innate lymphoid cells in the human female genital tract at homeostasis, uncovering tissue-specific and subset-specific distribution and functions, and Read More
Tags :Mucosal immunology
Epigenetic imprinting in innate lymphoid cell precursors directs the lineage
Nature Immunology, Published online: 18 September 2025; doi:10.1038/s41590-025-02261-0 Wang and colleagues show that specific DNA methylation profiles mark the ILC progenitors (ILCP) that would differentiate into ILC1, ILC2 or ILC3 subsets. Summary Wang Read More
Microbiota-mediated mechanisms of mucosal immunity across the lifespan – New
Nature Immunology, Published online: 16 September 2025; doi:10.1038/s41590-025-02281-w Here Iliev et al. review the interactions between the microbiota and the mucosal immune system from infancy to adulthood, highlighting the impact on health and Read More
Nature Reviews Immunology, Published online: 29 August 2025; doi:10.1038/s41577-025-01220-y A study by Bhattarai et al. in Nature Immunology reports that ILC3-to-ILC1 plasticity in the gut is regulated by circadian clock proteins. Summary Read More
CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits
Nature Immunology, Published online: 15 August 2025; doi:10.1038/s41590-025-02243-2 Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s. Summary A new study in Nature Immunology Read More
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02245-0 Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central Read More
Multimodal profiling reveals tissue-directed signatures of human immune cells altered
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02241-4 Wells et al. profile RNA and surface protein expression to describe dominant tissue-specific effects on immune cell composition and function across lineages in the human Read More
Circadian circuits control plasticity of group 3 innate lymphoid cells
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02240-5 Colonna and colleagues show that the clock genes encoding REV-ERBα and REV-ERBβ maintain ILC3 functions in the gut by controlling the expression of RORγt. Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02221-8 During late gestation, unconventional intraepithelial αβ T cells migrate from the gut to the mammary gland to remodel the tissue for lactation and enhance its mucosal Read More
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02218-3 Here Ramanan and colleagues provide an analysis of mammary T cells during late pregnancy and lactation. This revealed an increase in intraepithelial lymphocytes in the Read More