The endogenous T cell landscape is reshaped by CAR-T cell therapy and predicts treatment response in multiple myeloma Summary CAR-T cell therapy for multiple myeloma significantly alters the patient’s existing T cell population. This Read More
Tags :Medicine/Public Health
Education, Research & Positions
Next-generation T cell immunotherapies engineered with CRISPR base and prime
Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities Summary CRISPR base and prime editing offer promising avenues for enhancing T cell immunotherapies by precisely modifying the T cell genome. Read More
ICANS and mortality after CAR-T therapy for NHL patients can be predicted using physical function measures of falls, balance and strength deficits, and use of an assistive device Summary Physical function assessments can predict mortality Read More
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Enhanced patient selection with quantitative continuous scoring of PD-L1 expression
Enhanced patient selection with quantitative continuous scoring of PD-L1 expression for IO treatment in metastatic NSCLC Summary Quantitative, continuous scoring of PD-L1 expression offers improved patient selection for immunotherapy (IO) treatment in metastatic non-small cell Read More
Education, Research & Positions
EchoBack-CAR T cells: a sonogenetic solution to the persistent challenges
EchoBack-CAR T cells: a sonogenetic solution to the persistent challenges of solid tumor immunotherapy Summary EchoBack-CAR T cells offer a novel approach to solid tumor immunotherapy by addressing key limitations of traditional CAR T-cell therapies. Read More
Education, Research & Positions
Downregulation of MICA/MICB improves cell persistence and clinical activity of
Downregulation of MICA/MICB improves cell persistence and clinical activity of NKG2DL CAR T-cells in patients with relapsed or refractory acute myeloid leukemia or myelodysplastic neoplasia Summary CAR T-cell therapy targeting NKG2D ligands (Read More
Antigen-specific Treg cells induce infectious tolerance Summary Antigen-specific regulatory T cells (Tregs) can induce “infectious tolerance,” a powerful mechanism where Tregs not only suppress immune responses against a specific antigen but also convert other immune Read More
Education, Research & Positions
Plasmapheresis facilitates soluble BCMA clearance and contributes to reversing primary
Plasmapheresis facilitates soluble BCMA clearance and contributes to reversing primary resistance to anti-BCMA immunotherapy in multiple myeloma Summary Plasmapheresis, a procedure that filters blood, has shown promise in overcoming resistance to anti-BCMA immunotherapies for multiple Read More
Education, Research & Positions
UGCG and the glycosphingolipid rheostat: a metabolic checkpoint governing immune
UGCG and the glycosphingolipid rheostat: a metabolic checkpoint governing immune activation and tumor immune evasion Summary UDP-glucose ceramide glucosyltransferase (UGCG) controls the “glycosphingolipid rheostat,” a metabolic checkpoint pivotal in immune responses and tumor immune evasion. Read More
Education, Research & Positions
Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion
Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells Summary Targeting STAT3 specifically in neutrophils, a type of white blood cell, significantly hinders tumor progression, according to this research. Read More
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