lymphoid Archives

Spatial and functional diversity of innate lymphoid cells in the

Dr AF Saeed Dr AF Saeed 22nd September 2025

Nature Immunology, Published online: 22 September 2025; doi:10.1038/s41590-025-02285-6 The authors spatially and functionally map innate lymphoid cells in the human female genital tract at homeostasis, uncovering tissue-specific and subset-specific distribution and functions, and Read More

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Epigenetic imprinting in innate lymphoid cell precursors directs the lineage

Dr AF Saeed Dr AF Saeed 18th September 2025

Nature Immunology, Published online: 18 September 2025; doi:10.1038/s41590-025-02261-0 Wang and colleagues show that specific DNA methylation profiles mark the ILC progenitors (ILCP) that would differentiate into ILC1, ILC2 or ILC3 subsets. Summary Wang Read More

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Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses

Dr AF Saeed Dr AF Saeed 2nd September 2025

Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity Summary Activating both the STING and lymphotoxin-β receptor (LTβR) pathways concurrently enhances B cell-mediated antitumor immunity. Read More

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Clock genes tune plasticity of group 3 innate lymphoid cells

Dr AF Saeed Dr AF Saeed 13th August 2025

Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02245-0 Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central Read More

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Circadian circuits control plasticity of group 3 innate lymphoid cells

Dr AF Saeed Dr AF Saeed 13th August 2025

Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02240-5 Colonna and colleagues show that the clock genes encoding REV-ERBα and REV-ERBβ maintain ILC3 functions in the gut by controlling the expression of RORγt. Read More