Lymphocyte activation Archives

Agonistic immune checkpoint regulator may harm the heart

Dr AF Saeed Dr AF Saeed 9th July 2025

Agonistic immune checkpoint regulator may harm the heart Summary Agonistic immune checkpoint regulators (AICRs), designed to enhance anti-tumor immunity, may pose a risk to the heart. While AICRs like CD40 agonists are showing promise in Read More

Education, Research & Positions

Is immune effector cell-associated enterocolitis a CAR T-cell lymphoproliferative disorder?

Dr AF Saeed Dr AF Saeed 4th July 2025

Is immune effector cell-associated enterocolitis a CAR T-cell lymphoproliferative disorder? Summary Immune effector cell-associated enterocolitis (IEC-associated enterocolitis) can manifest after CAR T-cell therapy, presenting with gastrointestinal inflammation. While resembling graft-versus-host disease (GVHD), it’s often Read More

Education, Research & Positions

CD4<sup>+</sup> T cells license Kupffer cells to reverse CD8<sup>+</sup> T

Dr AF Saeed Dr AF Saeed 1st July 2025

Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02199-3 Here the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining Read More