Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02280-x Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis. Summary A study published in Read More
Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02255-y Alatrakchi and colleagues profile immune cells from liver and blood obtained from patients with MASLD/MASH using single-cell sequencing. They note increased immunoregulatory programs that Read More
Nature Immunology, Published online: 18 August 2025; doi:10.1038/s41590-025-02230-7 Latz et al. review the molecular mechanisms that drive NLRP3 inflammasome activation and regulation, and discuss emerging targeting strategies. Summary In a review published in Read More
Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2 Summary Regulatory T cell (Treg) therapy, intended to suppress inflammation, can paradoxically trigger inflammatory responses in certain contexts. Research Read More
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