Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis Summary A Mendelian randomization study explored the causal link between immune cell types (immunophenotypes) and HIV-1 acquisition. Using genetic variants as proxies for Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02213-8 FOXP3 dependence Summary A new study published in Nature Immunology reveals a crucial dependency on the transcription factor FOXP3 for the sustained suppressive function of Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02216-5 Neurons protect against fibrosis Summary New research published in Nature Immunology reveals a surprising role for neurons in preventing fibrosis. The study demonstrates that neurons, Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02214-7 Train your histones Summary A newly published Nature Immunology article highlights the potential for “training” histones, proteins around which DNA is wrapped, to influence immune Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02215-6 Y do T cells fail Summary A new study published in Nature Immunology (June 30, 2025) investigates the mechanisms behind T cell exhaustion. The research delves into Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02222-7 As interest in tissue-resident immunity, mucosal vaccines and host–microbiota interactions increases, barrier immunology stands at the forefront of immune defense. Summary Barrier immunology is Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02199-3 Here the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02191-x Tumor-associated macrophages are pivotal in control over solid tumors. Here the authors show that these macrophages express chemosensors that detect lipid variants in the tumor Read More
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