Nature Immunology, Published online: 21 July 2025; doi:10.1038/s41590-025-02229-0 Giardia intestinalis is a protozoan parasite that can cause severe enteric disease. The immune response to this organism provides unexpected benefits to limit gut inflammation. Read More
Tags :Infectious diseases
Nature Immunology, Published online: 21 July 2025; doi:10.1038/s41590-025-02227-2 Tran et al. discuss the role of the gut microbiome and gut microbiome-derived metabolites in T cell biology. Summary Tran et al.’s Nature Immunology Read More
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Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a
Oncolytic virus-mediated p53 activation boosts the antitumor immunity of a p53-transduced dendritic cell vaccine Summary This research explores combining oncolytic viruses and p53-enhanced dendritic cell (DC) vaccines to improve cancer immunotherapy. Specifically, DCs Read More
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Noncanonical and mortality-defining toxicities of CAR T cell therapy –
Noncanonical and mortality-defining toxicities of CAR T cell therapy Summary CAR T-cell therapy, while revolutionary, can trigger severe toxicities beyond the well-known cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). These less Read More
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Mitochondrial respiration is necessary for CD8<sup>+</sup> T cell proliferation and
Nature Immunology, Published online: 16 July 2025; doi:10.1038/s41590-025-02202-x Mitochondrial electron transport chain activity provides ATP, generates superoxide, regulates apoptosis and provides the biosynthetic building blocks for growing cells. Here Steinert et al. genetically Read More
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DNA hypomethylation traits define human regulatory T cells in cutaneous
Nature Immunology, Published online: 16 July 2025; doi:10.1038/s41590-025-02210-x Feuerer and colleagues use multiomic analyses to identify DNA methylation, chromatin accessibility and gene expression programs that govern the tissue adaptation of human skin Treg Read More
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Migrating immune cells globally coordinate protrusive forces – New Study
Nature Immunology, Published online: 15 July 2025; doi:10.1038/s41590-025-02211-w Sixt and colleagues show that, in environments where even the largest pores preclude free passage, leukocytes position their nucleus behind the centrosome and assemble a Read More
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IL-4 impairs the formation of skin-resident memory CD8<sup>+</sup> T cells
Nature Immunology, Published online: 14 July 2025; doi:10.1038/s41590-025-02207-6 Bromley and colleagues show that IL-4 decreases the responsiveness of CD8+ T cells to TGFβ, resulting in impaired formation of CD8+ TRM cells. Summary Bromley Read More
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A liver-centric help circuit revives CD8<sup>+</sup> T cells via IL-27
Nature Immunology, Published online: 08 July 2025; doi:10.1038/s41590-025-02204-9 Effector CD4⁺ T cells restore antiviral CD8⁺ T cell function in the liver by licensing Kupffer cells via CD40–CD40L interactions. This triggers IL-27 Read More
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Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in
Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial Summary This phase 1 clinical trial investigated the safety and efficacy of intracerebroventricular (ICV) administration of bivalent CAR T cells Read More
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