Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02249-w Carboxylation switch Summary A groundbreaking study published in Nature Immunology reveals a novel “carboxylation switch” mechanism in immune regulation. Researchers discovered that specific immune cells Read More
Tags :Infectious diseases
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02251-2 TLRs are blind to pseudouridine RNA Summary A new study published in Nature Immunology reveals that Toll-like receptors (TLRs), key components of the innate immune Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02248-x Targeting CAFs Summary Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment, influencing cancer progression, metastasis, and immune evasion. This Nature Immunology article Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02250-3 Restoring balanced HSC youth Summary A recent Nature Immunology article highlights promising research aimed at rejuvenating aged hematopoietic stem cells (HSCs). HSCs, responsible for generating Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02201-y TGFβ-mediated signals enable CD8+ T cells to establish tissue-residence. IL-4 and PD-1 are each connected to TGFβ signaling to regulate the formation of CD8+ Read More
Education, Research & Positions
Anti-tumor immunity is boosted by loss of TGFβ-driven tissue residency
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02224-5 Tumor-infiltrating CD8+ T cells acquire HOBIT expression and features of tissue-resident memory cells. This TGFβ-driven process is dispensable for tumor control by immune checkpoint Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02221-8 During late gestation, unconventional intraepithelial αβ T cells migrate from the gut to the mammary gland to remodel the tissue for lactation and enhance its mucosal Read More
Education, Research & Positions
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02218-3 Here Ramanan and colleagues provide an analysis of mammary T cells during late pregnancy and lactation. This revealed an increase in intraepithelial lymphocytes in the Read More
Education, Research & Positions
The impact of genetic immune disorders on infections including COVID-19,
Nature Immunology, Published online: 28 July 2025; doi:10.1038/s41590-025-02225-4 Cui et al. discuss new molecular and cellular insights underlying the pathogenesis of rare human diseases that arise from genetic inborn errors of immunity. Summary Read More
Nature Immunology, Published online: 25 July 2025; doi:10.1038/s41590-025-02244-1 Adoptive T cell therapies show limited efficacy against solid tumors owing to T cell exhaustion within the tumor microenvironment. A study now reveals that dysregulated Read More
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