Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02245-0 Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central Read More
Tags :Infectious diseases
Education, Research & Positions
Multimodal profiling reveals tissue-directed signatures of human immune cells altered
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02241-4 Wells et al. profile RNA and surface protein expression to describe dominant tissue-specific effects on immune cell composition and function across lineages in the human Read More
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Circadian circuits control plasticity of group 3 innate lymphoid cells
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02240-5 Colonna and colleagues show that the clock genes encoding REV-ERBα and REV-ERBβ maintain ILC3 functions in the gut by controlling the expression of RORγt. Read More
Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02246-z A complex of the NF-κB family member p52 and the transcription factor ETS1 is required for B cell germinal center responses to T cell-dependent Read More
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A STUB1–CHIC2 complex inhibits CD8<sup>+</sup> T cells to restrain tumor
Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02231-6 LaFleur, Milling et al. perform an in vivo CRISPR screen of CD8+ T cells responding to tumors. They identify the E3 ubiquitin ligase STUB1 as Read More
Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02234-3 Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the Read More
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Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer:
Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results Summary The AMPLIFY-201 phase 1 trial evaluated a novel lymph node-targeted vaccine targeting the mKRAS mutation in patients with pancreatic and Read More
Nature Immunology, Published online: 11 August 2025; doi:10.1038/s41590-025-02237-0 CD4+ T cells migrate from the gut and adipose tissue to the brain parenchyma, in mouse and human, transmitting information on diet and microbiome to Read More
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TCF19 drives a broad transcriptional program that potentiates optimal innate
Nature Immunology, Published online: 08 August 2025; doi:10.1038/s41590-025-02238-z Sun and colleagues report that the transcription factor TCF19 regulates calcium signaling and cell cycling progression in NK cells and is required for innate and Read More
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Pembrolizumab plus axitinib versus sunitinib for advanced clear cell renal
Pembrolizumab plus axitinib versus sunitinib for advanced clear cell renal cell carcinoma: 5-year survival and biomarker analyses of the phase 3 KEYNOTE-426 trial Summary The KEYNOTE-426 trial investigated pembrolizumab plus axitinib versus sunitinib for advanced clear Read More
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