Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02257-w Cui and colleagues identify the chromatin organizer protein SATB1 as a critical regulator of quiescence in stem-like progenitor CD8+ T cells that arise during chronic Read More
Tags :Infectious diseases
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GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/phase
GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/phase 2 trial Summary This Phase 1/Phase 2 trial investigates the safety and efficacy of GD2-targeted CAR T cell therapy in patients with high-risk neuroblastoma, a Read More
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Editorial Expression of Concern: Bcl-6 mediates the germinal center B
Nature Immunology, Published online: 20 August 2025; doi:10.1038/s41590-025-02264-x Editorial Expression of Concern: Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR Summary Nature Immunology Read More
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First-line sacituzumab tirumotecan with tagitanlimab in advanced non-small-cell lung cancer:
First-line sacituzumab tirumotecan with tagitanlimab in advanced non-small-cell lung cancer: a phase 2 trial Summary A phase 2 trial investigated sacituzumab tirumotecan combined with tagitanlimab as a first-line treatment for advanced non-small-cell lung cancer (NSCLC). The study Read More
Nature Immunology, Published online: 18 August 2025; doi:10.1038/s41590-025-02235-2 The authors show that the m6A reader protein YTHDF2 negatively regulates Th9 cell differentiation and function. Ablation of YTHDF2 promotes antigen-specific Th9 cell and Read More
A little less reading, a little more type 9 action Summary Okay, here’s a summary in approximately 100 words, assuming “type 9 action” refers to the Enneagram Type 9 personality type known for its peace-seeking and conflict-avoidant tendencies: Read More
Nature Immunology, Published online: 18 August 2025; doi:10.1038/s41590-025-02230-7 Latz et al. review the molecular mechanisms that drive NLRP3 inflammasome activation and regulation, and discuss emerging targeting strategies. Summary In a review published in Read More
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Proteogenomic approach to immunopeptidomics of ovarian tumors identifies shared peptide
Proteogenomic approach to immunopeptidomics of ovarian tumors identifies shared peptide vaccine candidates Summary A proteogenomic approach was used to analyze ovarian tumors, combining genomic and proteomic data with immunopeptidomics to identify potential shared peptide vaccine Read More
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CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits
Nature Immunology, Published online: 15 August 2025; doi:10.1038/s41590-025-02243-2 Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s. Summary A new study in Nature Immunology Read More
Education, Research & Positions
Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG
Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial Summary The SWOG S1512 phase 2 trial investigated pembrolizumab (anti-PD-1 therapy) in patients with unresectable desmoplastic melanoma (DM), a rare and aggressive subtype. The study Read More
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