Nature Immunology, Published online: 11 September 2025; doi:10.1038/s41590-025-02270-z The thymus is sensitive to acute insults including infection, as well as to injury from chemotherapy and myeloablative conditioning before hematopoietic cell transplantation. Here, Granadier Read More
T cells engineered to target a shared β-catenin mutation eradicate solid tumors in mice Summary Genetically engineered T cells targeting a specific mutation in the β-catenin protein have shown remarkable success in eradicating solid tumors Read More
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial Summary A phase 1/2 clinical trial investigated the safety and efficacy of GD2-targeting CAR T cells in children and young adults with Read More
Nature Immunology, Published online: 09 September 2025; doi:10.1038/s41590-025-02278-5 Cholesterol-dependent cytolysins produced by diverse bacterial pathogens are internalized by host cells and translocate to the trans-Golgi network (TGN). They remodel the TGN into a Read More
Nature Immunology, Published online: 09 September 2025; doi:10.1038/s41590-025-02258-9 Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and Read More
Nature Immunology, Published online: 08 September 2025; doi:10.1038/s41590-025-02263-y Erlich et al. show that soluble LTα and membrane-bound LTα1β2 lymphotoxins expressed by B cells play distinct roles to attenuate the pathology observed in ileitis. Read More
Nature Immunology, Published online: 05 September 2025; doi:10.1038/s41590-025-02293-6 Publisher Correction: TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells Summary The Nature Immunology paper, originally published online Read More
Nature Immunology, Published online: 05 September 2025; doi:10.1038/s41590-025-02269-6 The pre-T cell receptor is essential for T cell development. It is also an emerging immunotherapy target. Summary The pre-T cell receptor (pre-TCR) is crucial Read More
Nature Immunology, Published online: 05 September 2025; doi:10.1038/s41590-025-02277-6 Chen and colleagues show that type A cholesterol-dependent cytolysins, a group of bacteria pore-forming toxins, translocate to the trans-Golgi network to remodel it into a Read More
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity Summary Activating both the STING and lymphotoxin-β receptor (LTβR) pathways concurrently enhances B cell-mediated antitumor immunity. Read More
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