Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02231-6 LaFleur, Milling et al. perform an in vivo CRISPR screen of CD8+ T cells responding to tumors. They identify the E3 ubiquitin ligase STUB1 as Read More
Nature Immunology, Published online: 12 August 2025; doi:10.1038/s41590-025-02234-3 Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the Read More
Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results Summary The AMPLIFY-201 phase 1 trial evaluated a novel lymph node-targeted vaccine targeting the mKRAS mutation in patients with pancreatic and Read More
Nature Immunology, Published online: 11 August 2025; doi:10.1038/s41590-025-02237-0 CD4+ T cells migrate from the gut and adipose tissue to the brain parenchyma, in mouse and human, transmitting information on diet and microbiome to Read More
Nature Immunology, Published online: 08 August 2025; doi:10.1038/s41590-025-02238-z Sun and colleagues report that the transcription factor TCF19 regulates calcium signaling and cell cycling progression in NK cells and is required for innate and Read More
Pembrolizumab plus axitinib versus sunitinib for advanced clear cell renal cell carcinoma: 5-year survival and biomarker analyses of the phase 3 KEYNOTE-426 trial Summary The KEYNOTE-426 trial investigated pembrolizumab plus axitinib versus sunitinib for advanced clear Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02249-w Carboxylation switch Summary A groundbreaking study published in Nature Immunology reveals a novel “carboxylation switch” mechanism in immune regulation. Researchers discovered that specific immune cells Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02251-2 TLRs are blind to pseudouridine RNA Summary A new study published in Nature Immunology reveals that Toll-like receptors (TLRs), key components of the innate immune Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02248-x Targeting CAFs Summary Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment, influencing cancer progression, metastasis, and immune evasion. This Nature Immunology article Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02250-3 Restoring balanced HSC youth Summary A recent Nature Immunology article highlights promising research aimed at rejuvenating aged hematopoietic stem cells (HSCs). HSCs, responsible for generating Read More
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