Nature Immunology, Published online: 22 September 2025; doi:10.1038/s41590-025-02285-6 The authors spatially and functionally map innate lymphoid cells in the human female genital tract at homeostasis, uncovering tissue-specific and subset-specific distribution and functions, and Read More
Tags :Infectious diseases
Education, Research & Positions
Precise inhibition of pyroptotic pores presents new opportunities for inflammation
Nature Immunology, Published online: 19 September 2025; doi:10.1038/s41590-025-02294-5 The artificial intelligence (AI)-designed peptide SK56 blocks mature gasdermin D pores, delaying pyroptosis and inflammatory cytokine release. This reduces dendritic cell hyperactivation and prevents Read More
Education, Research & Positions
STING signals to NF-κB from late endolysosomal compartments using IRF3
Nature Immunology, Published online: 19 September 2025; doi:10.1038/s41590-025-02283-8 Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling. Summary Read More
Nature Immunology, Published online: 18 September 2025; doi:10.1038/s41590-025-02275-8 The effector fates of innate lymphoid cells (ILCs) are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding Read More
Education, Research & Positions
Epigenetic imprinting in innate lymphoid cell precursors directs the lineage
Nature Immunology, Published online: 18 September 2025; doi:10.1038/s41590-025-02261-0 Wang and colleagues show that specific DNA methylation profiles mark the ILC progenitors (ILCP) that would differentiate into ILC1, ILC2 or ILC3 subsets. Summary Wang Read More
Nature Immunology, Published online: 16 September 2025; doi:10.1038/s41590-025-02284-7 CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, Read More
Education, Research & Positions
Microbiota-mediated mechanisms of mucosal immunity across the lifespan – New
Nature Immunology, Published online: 16 September 2025; doi:10.1038/s41590-025-02281-w Here Iliev et al. review the interactions between the microbiota and the mucosal immune system from infancy to adulthood, highlighting the impact on health and Read More
Education, Research & Positions
A spatial map of MAPK-activated immunosuppressive myeloid populations in pediatric
Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02268-7 Here the authors spatially map human pediatric low-grade gliomas using imaging mass cytometry, focusing on immunosuppressive myeloid cell populations and their functionality in tumor–immune Read More
Education, Research & Positions
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates
Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02280-x Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis. Summary A study published in Read More
Education, Research & Positions
Lymph nodes fuel KLF2-dependent effector CD8<sup>+</sup> T cell differentiation during
Nature Immunology, Published online: 15 September 2025; doi:10.1038/s41590-025-02276-7 Here the authors show a function for lymph nodes in the maintenance of effector T cell differentiation and function during chronic infection and checkpoint blockade, Read More
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