Evolutionary regulation of human Fas ligand (CD95L) by plasmin in solid cancer immunotherapy Summary Human Fas ligand (CD95L) is a key player in immune cell-mediated killing of cancer cells. However, cancer cells can Read More
Tags :immunotherapy
Education, Research & Positions
Different tumour-resident memory T-cell subsets regulate responses to anti-PD-1 and
Different tumour-resident memory T-cell subsets regulate responses to anti-PD-1 and anti-CTLA-4 cancer immunotherapies Summary Tumour-resident memory T cells (Trm) are critical for effective cancer immunotherapy, but their heterogeneity and specific roles remain unclear. Research reveals Read More
Education, Research & Positions
Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian
Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis Summary A Mendelian randomization study explored the causal link between immune cell types (immunophenotypes) and HIV-1 acquisition. Using genetic variants as proxies for Read More
CAR T cell therapy for children with rheumatic disease: the time is now Summary CAR T-cell therapy, traditionally used for cancer, is showing promise in treating severe, refractory rheumatic diseases in children. These diseases often Read More
Education, Research & Positions
PPP2R1A mutations portend improved survival after cancer immunotherapy
PPP2R1A mutations portend improved survival after cancer immunotherapy Summary Mutations in the PPP2R1A gene, encoding a scaffolding subunit of the PP2A phosphatase complex, are linked to better survival outcomes in Read More
Education, Research & Positions
Rewiring endogenous genes in CAR T cells for tumour-restricted payload
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery Summary Rewiring CAR T cells to deliver therapeutic payloads directly within the tumor microenvironment offers a promising strategy to enhance efficacy and reduce systemic Read More
Education, Research & Positions
Orchestrating intratumoral DC-T cell immunity for enhanced tumor control via
Orchestrating intratumoral DC-T cell immunity for enhanced tumor control via radiotherapy-activated TLR7/8 prodrugs in mice Summary Researchers developed a novel approach combining radiotherapy (RT) with TLR7/8 agonist prodrugs activated by RT within tumors in mice. Read More
Education, Research & Positions
A lentiviral vector targeting a KRAS neoepitope for cancer immunotherapy
A lentiviral vector targeting a KRAS neoepitope for cancer immunotherapy Summary Researchers have developed a lentiviral vector to deliver a neoepitope derived from a common KRAS mutation (G12D) directly to antigen-presenting cells (APCs). This Read More
Education, Research & Positions
Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny
Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny Summary Researchers have developed a novel approach to target cancer using modified hematopoietic stem cells (HSCs). They engineer HSCs to express a tumor-specific T cell receptor (Read More
Education, Research & Positions
Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment
Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation Summary Metabotropic glutamate receptor 4 (mGluR4) signaling in dendritic cells (DCs) significantly alters the tumor microenvironment. Activation of mGluR4, a glutamate Read More
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