Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma Summary Glioblastoma, a deadly brain cancer, often evades immune responses. This research explores a new strategy to boost immunosurveillance by targeting necrotic Read More
The liver metabolizes dietary galactose to fuel antitumour T cell immunity Summary Dietary galactose, often overlooked, plays a crucial role in fueling anti-tumor T cell responses, particularly when metabolized in the liver. The liver’s Read More
Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function Summary This study investigates the relationship between the functional avidity of anti-B7H3 CAR-T cells and the antigen density required Read More
Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02224-5 Tumor-infiltrating CD8+ T cells acquire HOBIT expression and features of tissue-resident memory cells. This TGFβ-driven process is dispensable for tumor control by immune checkpoint Read More
Autoantibody spark response predicts treatment outcome in patients receiving chemoradiation followed by durvalumab therapy Summary A study revealed that the development of new autoantibodies, termed “autoantibody spark,” following chemoradiation therapy (CRT) predicts the effectiveness of Read More
The microbiota in radiotherapy-induced cancer immunosurveillance Summary Radiotherapy (RT) can trigger anti-tumor immune responses, a process known as immunosurveillance. The gut microbiota plays a crucial role in modulating this process. RT-induced changes in the gut Read More
Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs Summary Delivering plasmids encoding IL-12 and CD40L (CD154) directly into tumors can effectively trigger antitumor immunity. Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02191-x Tumor-associated macrophages are pivotal in control over solid tumors. Here the authors show that these macrophages express chemosensors that detect lipid variants in the tumor Read More
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