CD99-mediated immunological synapse formation potentiates CAR-T cell function Summary CD99, a cell surface protein, plays a crucial role in enhancing the efficacy of CAR-T cell therapy. By facilitating the formation of a stable immunological Read More
Immunological features of clear-cell renal-cell carcinoma and resistance to immune checkpoint inhibitors Summary Clear-cell renal cell carcinoma (ccRCC) is characterized by immune infiltration, but often exhibits resistance to immune checkpoint inhibitors (ICIs). Several factors contribute Read More
By linking bacterial polysaccharides to carrier proteins, conjugate vaccines transform weak antigens into triggers of lasting T cell-dependent immunity. Summary Conjugate vaccines boost the immune system by linking bacterial polysaccharides (sugars) to carrier proteins. Bacterial Read More
CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation Summary Augmenting CAR-T cells with CD2 enhances their anti-tumor efficacy by improving the immunological synapse. This involves restructuring the synapse architecture for Read More
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