Immunoediting Archives

Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment –

Dr AF Saeed Dr AF Saeed 22nd August 2025

Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment Summary Cancer cells often produce high levels of lactic acid, creating an immunosuppressive microenvironment. This study investigates targeting the MondoA-TXNIP pathway in this lactic acid-rich Read More

Education, Research & Positions

CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and

Dr AF Saeed Dr AF Saeed 4th July 2025

CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation Summary Augmenting CAR-T cells with CD2 enhances their anti-tumor efficacy by improving the immunological synapse. This involves restructuring the synapse architecture for Read More

Education, Research & Positions

Suppression of multiple mouse models of refractory malignancies by reprogramming

Dr AF Saeed Dr AF Saeed 3rd July 2025

Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction Summary Researchers developed a novel immunotherapeutic strategy that reprograms the IL-18 pathway to combat refractory malignancies in mice. By engineering a “decoy” Read More