Immune evasion Archives

Empowering hypoxia to convert cold tumors into hot tumors for

Dr AF Saeed Dr AF Saeed 14th August 2025

Empowering hypoxia to convert cold tumors into hot tumors for breast cancer immunotherapy Summary Recent research explores harnessing hypoxia, a common characteristic of “cold” tumors (those resistant to immunotherapy), to enhance breast cancer immunotherapy. By Read More

Education, Research & Positions

TLRs are blind to pseudouridine RNA – New Study

Dr AF Saeed Dr AF Saeed 29th July 2025

Nature Immunology, Published online: 29 July 2025; doi:10.1038/s41590-025-02251-2 TLRs are blind to pseudouridine RNA Summary A new study published in Nature Immunology reveals that Toll-like receptors (TLRs), key components of the innate immune Read More

Education, Research & Positions

Metabolic alterations driven by LDHA in CD8 + T cells promote immune

Dr AF Saeed Dr AF Saeed 8th July 2025

Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC Summary Lung cancer cells often evade the immune system by manipulating CD8+ T cells, the body’s primary Read More

Education, Research & Positions

TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance

Dr AF Saeed Dr AF Saeed 1st July 2025

TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing Summary TRPV1 inhibition can enhance the effectiveness of PD-1 blockade immunotherapy in treating tumors. Tumors can develop resistance to cytotoxic T lymphocyte (Read More