Different tumour-resident memory T-cell subsets regulate responses to anti-PD-1 and anti-CTLA-4 cancer immunotherapies Summary Tumour-resident memory T cells (Trm) are critical for effective cancer immunotherapy, but their heterogeneity and specific roles remain unclear. Research reveals Read More
Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma Summary Adrenocortical carcinoma (ACC) is an aggressive cancer with limited treatment options. This research Read More
Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis Summary A Mendelian randomization study explored the causal link between immune cell types (immunophenotypes) and HIV-1 acquisition. Using genetic variants as proxies for Read More
Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial Summary The SAGC trial, a randomized phase 2 study, investigated the efficacy of sintilimab (a PD-1 inhibitor) and anlotinib (Read More
PPP2R1A mutations portend improved survival after cancer immunotherapy Summary Mutations in the PPP2R1A gene, encoding a scaffolding subunit of the PP2A phosphatase complex, are linked to better survival outcomes in Read More
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery Summary Rewiring CAR T cells to deliver therapeutic payloads directly within the tumor microenvironment offers a promising strategy to enhance efficacy and reduce systemic Read More
Orchestrating intratumoral DC-T cell immunity for enhanced tumor control via radiotherapy-activated TLR7/8 prodrugs in mice Summary Researchers developed a novel approach combining radiotherapy (RT) with TLR7/8 agonist prodrugs activated by RT within tumors in mice. Read More
A lentiviral vector targeting a KRAS neoepitope for cancer immunotherapy Summary Researchers have developed a lentiviral vector to deliver a neoepitope derived from a common KRAS mutation (G12D) directly to antigen-presenting cells (APCs). This Read More
Donor and recipient genetic variants in drug metabolizing enzymes and transporters affect early tacrolimus pharmacokinetics after liver transplantation Summary Genetic variations in both liver transplant donors and recipients impact how the body processes tacrolimus, a Read More
Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny Summary Researchers have developed a novel approach to target cancer using modified hematopoietic stem cells (HSCs). They engineer HSCs to express a tumor-specific T cell receptor (Read More
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