The unfolded protein response influences therapy outcome and disease progression in chronic lymphocytic leukaemia Summary Chronic lymphocytic leukemia (CLL) cells rely on the unfolded protein response (UPR), a cellular stress response pathway, to survive. The Read More
Autoantibody spark response predicts treatment outcome in patients receiving chemoradiation followed by durvalumab therapy Summary A study revealed that the development of new autoantibodies, termed “autoantibody spark,” following chemoradiation therapy (CRT) predicts the effectiveness of Read More
The oncolytic adenovirus Ad-TD-nsIL12 in primary or progressive pediatric IDH wild-type diffuse intrinsic pontine glioma results of two phase I clinical trials Summary Two Phase I clinical trials evaluated the safety and efficacy of Ad-TD-nsIL12, Read More
A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade Summary This research presents a novel CD27 agonistic antibody engineered for enhanced activity. By promoting hexamerization (Read More
Humoral determinants of checkpoint immunotherapy Summary Humoral factors, like antibodies and complement proteins, play a crucial but often overlooked role in checkpoint immunotherapy efficacy. Beyond T-cell activation, checkpoint inhibitors can influence antibody-dependent cellular cytotoxicity (ADCC) Read More
Resolving the structural basis of therapeutic antibody function in cancer immunotherapy with RESI Summary RESI, or Relative Entropy Scanning of Interactions, is a computational approach that identifies key amino acid residues in antibody-antigen interactions crucial Read More
Cooperative role of MDSCs and Tregs in alum-induced alloimmune tolerance in corneal transplantation Summary Alum, a common vaccine adjuvant, can induce alloimmune tolerance in corneal transplantation by fostering a collaborative relationship between myeloid-derived suppressor cells (Read More
Nanomechanical binding mechanism of ligands drives agonistic activity Summary Ligand binding to receptors triggers biological responses, but the precise mechanism remains unclear. Recent research highlights the crucial role of nanomechanical forces in this process. Ligand Read More
Microbiota-driven antitumour immunity mediated by dendritic cell migration Summary The gut microbiota plays a crucial role in shaping anti-tumor immunity. Specific gut bacteria stimulate the migration of dendritic cells (DCs) from the gut to tumor Read More
Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma Summary A multomic analysis of osteosarcoma (OS) reveals LAG3’s potential as a significant prognostic and immune Read More
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