Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function Summary This study investigates the relationship between the functional avidity of anti-B7H3 CAR-T cells and the antigen density required Read More
Real-world study of first-line immunotherapy combined with chemoradiotherapy in esophageal squamous cell carcinoma Summary A real-world study investigated the efficacy of first-line immunotherapy (likely PD-1/PD-L1 inhibitors) combined with chemoradiotherapy (CRT) in patients with esophageal Read More
Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles Summary This research explores a novel approach to combat lung metastasis and recurrence by using CAR (Chimeric Antigen Read More
Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy Summary This research explores a novel approach to improve immunotherapy response in Triple-Negative Breast Cancer (TNBC) using chimeric exosomes. These engineered exosomes, derived from Read More
IC2Bert: masked gene expression pretraining and supervised fine tuning for robust immune checkpoint blockade (ICB) response prediction Summary IC2Bert proposes a novel deep learning framework for predicting patient response to Immune Checkpoint Blockade (Read More
Caerin 1.1/1.9 interfere KHDRBS1-DDX5 regulatory axis to induce IL-18 mediated pyroptosis in a HeLa cell tumour model Summary Caerin 1.1 and 1.9, peptides, disrupt the KHDRBS1-DDX5 regulatory axis in HeLa cancer cells. This disruption triggers IL-18 Read More
Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition Summary Tumor-associated neutrophil precursors (TANPs) disrupt homologous recombination (HR), a crucial DNA repair mechanism, in cancer cells. TANPs achieve this by secreting Read More
Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life Summary Delivering broadly neutralizing antibodies (bNAbs) against HIV-1 via adeno-associated virus (AAV) vectors in early life holds promise for HIV prevention. Success hinges on Read More
The value of acetylation reader YEATS2 in hepatocellular carcinoma management Summary YEATS2, a protein that “reads” acetylated lysine on histones, plays a significant role in hepatocellular carcinoma (HCC) development. Studies indicate it promotes HCC cell Read More
AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression Summary Prostate cancer progression can be fueled by a specific type of macrophage called AR+TREM2+ macrophages. These macrophages, characterized by the androgen receptor (AR) Read More
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