The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response Summary The epiMelanoma test is a blood-based diagnostic tool offering a non-invasive method for melanoma detection and prediction of response to immunotherapy. Read More
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy Summary Cancer-induced nerve damage can foster resistance to anti-PD-1 immunotherapy. Specifically, nerves damaged by the tumor release neuropeptides that suppress immune cell activity, particularly T cell function. Read More
Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma Summary Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive lung cancer with limited treatment options. Recent research has aimed to comprehensively Read More
Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2 Summary Regulatory T cell (Treg) therapy, intended to suppress inflammation, can paradoxically trigger inflammatory responses in certain contexts. Research Read More
Expanding the cytokine receptor alphabet reprograms T cells into diverse states Summary T cells, traditionally defined by a limited set of cytokine receptors, can be drastically reprogrammed by expanding this “receptor alphabet.” Research demonstrates that Read More
CARG-2020 targets IL-12, IL-17, and PD-L1 pathways to effectively treat melanoma and breast cancer Summary CARG-2020 is a novel therapeutic strategy designed to treat melanoma and breast cancer by simultaneously targeting three crucial pathways involved Read More
Epigenetic modulation with nanosatellite triggers tumoricidal immunity for hepatocellular carcinoma treatment Summary Researchers have developed a novel approach to treat hepatocellular carcinoma (HCC) by combining epigenetic modulation with nanosatellite delivery to trigger an anti-tumor immune Read More
Investigating the correlation between IDO1/PD-L1 expression or co-expression and EGFR/KRAS gene mutations in advanced NSCLC Summary This study explores the relationship between IDO1 and PD-L1 expression (both individually and together) and the presence Read More
Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target Summary This study used a comprehensive “multi-omics” approach (combining genomics, proteomics, etc.) to understand the T-cell environment Read More
Sorafenib-treated Th9 cells exhibit superior anti-tumor effect in lung metastasis Summary Sorafenib, a multi-kinase inhibitor, enhances the anti-tumor activity of Th9 cells (a type of T helper cell) in lung metastasis models. Specifically, sorafenib treatment Read More
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