Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer Summary Activation of the PPARγ pathway shows promise in improving CAR T cell therapy for bladder cancer. Read More
Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA Summary Inhaled RNA targeting HSP47, a key collagen chaperone, can modulate tumor collagen fiber alignment and enhance immunotherapy efficacy in lung cancer. Read More
GD2TIF cells as a platform for single-dose and long-term delivery of biologics Summary GD2TIF cells, genetically engineered to express therapeutic molecules in response to tumor-specific GD2 disialoganglioside, hold promise for single-dose, long-term biologic Read More
Clonal diversity shapes the tumour microenvironment leading to distinct immunotherapy responses in metastatic urothelial carcinoma Summary Metastatic urothelial carcinoma (mUC) exhibits varying responses to immunotherapy, and clonal diversity within tumors plays a significant role in Read More
CD99-mediated immunological synapse formation potentiates CAR-T cell function Summary CD99, a cell surface protein, plays a crucial role in enhancing the efficacy of CAR-T cell therapy. By facilitating the formation of a stable immunological Read More
Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement Summary A multi-omics study reveals that acute myeloid leukemia (AML) with KMT2A rearrangement, following lineage switch, exhibits an immunosuppressive phenotype Read More
Polyclonal expansion of functional tumor-reactive lymphocytes infiltrating glioblastoma for personalized cell therapy Summary This research explores leveraging the body’s own immune system to fight glioblastoma, a deadly brain cancer. The study focuses on expanding Read More
Exploring the metabolic-immune score in advanced NSCLC treated with immunotherapy Summary This research investigates the relationship between a “metabolic-immune score” and outcomes in advanced Non-Small Cell Lung Cancer (NSCLC) patients treated with immunotherapy. The score Read More
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer Summary Pancreatic cancer often resists immunotherapy, and this resistance is linked to elevated levels of spermine, a polyamine involved in cell growth and survival. Researchers Read More
The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS Summary AFM28, a bispecific innate cell engager targeting CD123 and CD16A, demonstrates promising results in eliminating leukemic Read More
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