Exploring the metabolic-immune score in advanced NSCLC treated with immunotherapy Summary This research investigates the relationship between a “metabolic-immune score” and outcomes in advanced Non-Small Cell Lung Cancer (NSCLC) patients treated with immunotherapy. The score Read More
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer Summary Pancreatic cancer often resists immunotherapy, and this resistance is linked to elevated levels of spermine, a polyamine involved in cell growth and survival. Researchers Read More
The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS Summary AFM28, a bispecific innate cell engager targeting CD123 and CD16A, demonstrates promising results in eliminating leukemic Read More
The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response Summary The epiMelanoma test is a blood-based diagnostic tool offering a non-invasive method for melanoma detection and prediction of response to immunotherapy. Read More
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy Summary Cancer-induced nerve damage can foster resistance to anti-PD-1 immunotherapy. Specifically, nerves damaged by the tumor release neuropeptides that suppress immune cell activity, particularly T cell function. Read More
Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma Summary Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive lung cancer with limited treatment options. Recent research has aimed to comprehensively Read More
Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2 Summary Regulatory T cell (Treg) therapy, intended to suppress inflammation, can paradoxically trigger inflammatory responses in certain contexts. Research Read More
Expanding the cytokine receptor alphabet reprograms T cells into diverse states Summary T cells, traditionally defined by a limited set of cytokine receptors, can be drastically reprogrammed by expanding this “receptor alphabet.” Research demonstrates that Read More
CARG-2020 targets IL-12, IL-17, and PD-L1 pathways to effectively treat melanoma and breast cancer Summary CARG-2020 is a novel therapeutic strategy designed to treat melanoma and breast cancer by simultaneously targeting three crucial pathways involved Read More
Epigenetic modulation with nanosatellite triggers tumoricidal immunity for hepatocellular carcinoma treatment Summary Researchers have developed a novel approach to treat hepatocellular carcinoma (HCC) by combining epigenetic modulation with nanosatellite delivery to trigger an anti-tumor immune Read More
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