Epigenetic modulation with nanosatellite triggers tumoricidal immunity for hepatocellular carcinoma treatment Summary Researchers have developed a novel approach to treat hepatocellular carcinoma (HCC) by combining epigenetic modulation with nanosatellite delivery to trigger an anti-tumor immune Read More
The value of acetylation reader YEATS2 in hepatocellular carcinoma management Summary YEATS2, a protein that “reads” acetylated lysine on histones, plays a significant role in hepatocellular carcinoma (HCC) development. Studies indicate it promotes HCC cell Read More
Bifidobacterium boosts anti-PD-1 effectiveness through JAK pathway in hepatocellular carcinoma Summary A study reveals that Bifidobacterium species enhance the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma (HCC). The mechanism involves Bifidobacterium modulating the gut microbiome, Read More
IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma Summary Interferon-gamma (IFNγ) enhances the effectiveness of tyrosine kinase inhibitors (TKIs) in treating hepatocellular carcinoma (HCC) by mitigating protein Read More
Nature Immunology, Published online: 30 June 2025; doi:10.1038/s41590-025-02199-3 Here the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining Read More
SIRPα blockade therapy potentiates immunotherapy by inhibiting PD-L1+ myeloid cells in hepatocellular carcinoma Summary SIRPα blockade enhances immunotherapy effectiveness in hepatocellular carcinoma (HCC) by targeting a specific subset of myeloid cells. These myeloid cells, which Read More
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