A little less reading, a little more type 9 action Summary Okay, here’s a summary in approximately 100 words, assuming “type 9 action” refers to the Enneagram Type 9 personality type known for its peace-seeking and conflict-avoidant tendencies: Read More
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Nature Immunology, Published online: 18 August 2025; doi:10.1038/s41590-025-02230-7 Latz et al. review the molecular mechanisms that drive NLRP3 inflammasome activation and regulation, and discuss emerging targeting strategies. Summary In a review published in Read More
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Proteogenomic approach to immunopeptidomics of ovarian tumors identifies shared peptide
Proteogenomic approach to immunopeptidomics of ovarian tumors identifies shared peptide vaccine candidates Summary A proteogenomic approach was used to analyze ovarian tumors, combining genomic and proteomic data with immunopeptidomics to identify potential shared peptide vaccine Read More
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CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits
Nature Immunology, Published online: 15 August 2025; doi:10.1038/s41590-025-02243-2 Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s. Summary A new study in Nature Immunology Read More
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Impact of daratumumab refractoriness on clinical outcomes following CAR T-cell
Impact of daratumumab refractoriness on clinical outcomes following CAR T-cell therapy for relapsed refractory multiple myeloma Summary Daratumumab refractoriness significantly worsens outcomes after CAR T-cell therapy in patients with relapsed/refractory multiple myeloma. Studies show Read More
Empowering hypoxia to convert cold tumors into hot tumors for breast cancer immunotherapy Summary Recent research explores harnessing hypoxia, a common characteristic of “cold” tumors (those resistant to immunotherapy), to enhance breast cancer immunotherapy. By Read More
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Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG
Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial Summary The SWOG S1512 phase 2 trial investigated pembrolizumab (anti-PD-1 therapy) in patients with unresectable desmoplastic melanoma (DM), a rare and aggressive subtype. The study Read More
Nature Reviews Immunology, Published online: 14 August 2025; doi:10.1038/s41577-025-01211-z Tumour-associated blood vessels are abnormal in structure and function, and this can limit immune cell infiltration into tumours and contribute to the immunosuppressive tumour Read More
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02245-0 Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central Read More
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Multimodal profiling reveals tissue-directed signatures of human immune cells altered
Nature Immunology, Published online: 13 August 2025; doi:10.1038/s41590-025-02241-4 Wells et al. profile RNA and surface protein expression to describe dominant tissue-specific effects on immune cell composition and function across lineages in the human Read More
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