Engineering TCR-preserved allogeneic CAR-T cells: leveraging cancer immune evasion principles to establish T-cell tolerance Summary Engineering allogeneic CAR-T cells that retain their T cell receptor (TCR) could overcome challenges of current CAR-T therapies. By understanding Read More
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells Summary Researchers have developed a directed evolution approach to discover ligands that can specifically restimulate chimeric antigen receptor (CAR) T Read More
Ultrasound-enhanced Pt-coordinated polymer immunopotentiators and heterogenic fusion membrane-based multifunctional tumor vaccine nanoplatforms for melanoma treatment Summary This research explores a novel approach to melanoma treatment combining ultrasound-enhanced immunopotentiators and a multifunctional tumor vaccine nanoplatform. The Read More
Cascade amplification of therapeutic payloads for cancer immunotherapy Summary “Cascade amplification of therapeutic payloads” in cancer immunotherapy refers to strategies designed to enhance the efficacy of delivered drugs or immunomodulatory agents within the tumor microenvironment. Read More
Multiparametric cellular and spatial organization in cancer tissue lesions with a streamlined pipeline Summary This content focuses on analyzing cancer tissue using a comprehensive, multi-faceted approach. It combines cellular information (characteristics of individual cells) with Read More
Targeting LINC01711 in FAP+ cancer-associated fibroblasts overcomes lactate-mediated immunosuppression and enhances anti-PD-1 efficacy in lung adenocarcinoma Summary Targeting LINC01711 in cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) shows promise in overcoming immunosuppression in lung Read More
The impact of social determinants of health on outcomes of brexucabtagene autoleucel in adults with relapsed/refractory B-cell acute lymphoblastic leukemia Summary Social determinants of health (SDOH) significantly impact outcomes in adults with relapsed/refractory Read More
Personalized circulating tumor DNA dynamics inform survival and response to immune checkpoint blockade in recurrent/metastatic head and neck cancer Summary This study investigates the utility of personalized circulating tumor DNA (ctDNA) monitoring in patients Read More
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment Summary Cancer cells often produce high levels of lactic acid, creating an immunosuppressive microenvironment. This study investigates targeting the MondoA-TXNIP pathway in this lactic acid-rich Read More
Nature Immunology, Published online: 22 August 2025; doi:10.1038/s41590-025-02247-y Using in vivo CRISPR–Cas9 screens of CD8+ T cells in a melanoma model, we identified STUB1 as an inhibitor of T cell-mediated antitumor immunity. Read More
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